0000000001331841
AUTHOR
Janet Franklin
Durability of complete response after blinatumomab therapy for relapsed/refractory diffuse large B-cell lymphoma
Despite advances in standards of care, the prognosis of relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL) remains poor. In these patients, 50–74% fail to respond to next line therapy,...
Durability of complete response after blinatumomab therapy for refractory/relapsed aggressive B-cell non-Hodgkin lymphoma.
e19041 Background: Achieving durable response in patients (pts) with relapsed/refractory (R/R) aggressive B-cell lymphoma (B-NHL) is challenging. Blinatumomab, a bispecific T-cell engager (BiTE) immunotherapy targeting CD19-expressing cancer cells, has shown promising efficacy in pts with R/R aggressive B-NHL. We report the durability of complete response (DOCR) in pts treated with blinatumomab. Methods: The DOCR in pts with R/R aggressive B-NHL responding to blinatumomab was assessed using data from two phase 2 studies (study 1 [N = 25], NCT01741792; study 2 [N = 41], NCT02910063) in pts with R/R aggressive B-NHL. CR was assessed using Cheson (study 1) and Lugano (study 2) criteria. Time-…
Farmland Biodiversity Monitoring Practice in Europe and North America
Agriculture is one of the main causes for the strong declines in biodiversity over the last decades. To protect and promote farmland biodiversity effectively, politicians and farmers need information about the status and dynamics of biodiversity on agricultural land. We reviewed a number of large monitoring programs in Europe and North America and investigated design decisions, monitoring costs and informative value for stakeholders. Useful programs focus on the landscape scale and investigate the state and dynamics of habitats and one or better several organism groups, mainly plant species and faunal groups if financially feasible. They sample raw data stratified over intensive and remote …