6533b7cefe1ef96bd125701e

RESEARCH PRODUCT

Cytosporones, coumarins, and an alkaloid from the endophytic fungus Pestalotiopsis sp. isolated from the Chinese mangrove plant Rhizophora mucronata

Jandirk SendkerWerner E.g. MüllerJing XuRuangelie EdradaMirko BayerVictor WrayWenhan LinJulia KjerHuashi GuanJun WuPeter Proksch

subject

Spectrometry Mass Electrospray IonizationMagnetic Resonance SpectroscopyClinical BiochemistryPharmaceutical ScienceBiochemistryEndophyteCell Linechemistry.chemical_compoundAlkaloidsAscomycotaCoumarinsDrug DiscoveryBotanyAnimalsHumansPestalotiopsisMolecular BiologyRhizophora mucronatabiologyAlkaloidOrganic ChemistryRhizophoraceaePhenolic acidFungi imperfectibiology.organism_classificationchemistryRhizophoraceaeMolecular MedicineSpectrophotometry UltravioletMangrove

description

Chemical examination of the endophytic fungus Pestalotiopsis sp., isolated from the leaves of the Chinese mangrove Rhizophora mucronata, yielded 11 new compounds including cytosporones J-N (1-3, 5-6), five new coumarins pestalasins A-E (8-12), and a new alkaloid named pestalotiopsoid A (14), along with the known compounds cytosporone C (4), dothiorelone B (7), and 3-hydroxymethyl-6,8-dimethoxycoumarin (13). The structures of the new compounds were unambiguously elucidated on the basis of extensive spectroscopic data analysis.

yearjournalcountryeditionlanguage
2009-10-01Bioorganic & Medicinal Chemistry
https://doi.org/10.1016/j.bmc.2009.08.031