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RESEARCH PRODUCT
Protein Corona: Prevention of Dominant IgG Adsorption on Nanocarriers in IgG‐Enriched Blood Plasma by Clusterin Precoating (Adv. Sci. 10/2019)
Domenik ProzellerJohanna SimonJohanna SimonSvenja MorsbachVolker MailänderVolker MailänderJorge PereiraKatharina Landfestersubject
Back Coverstealth effectnanocarriersClusterinbiologyclusterinChemistryGeneral Chemical EngineeringGeneral EngineeringGeneral Physics and AstronomyMedicine (miscellaneous)Protein CoronaBiochemistry Genetics and Molecular Biology (miscellaneous)Molecular biologyImmunoglobulin Gimmunoglobulin Gprotein coronaAdsorptionBlood plasmabiology.proteinGeneral Materials ScienceNanocarriersdescription
The development of nanocarriers for drug delivery is challenged by individual blood composition fluctuations. In article number 1802199, Svenja Morsbach and co‐workers report the accumulation of immunoglobulins in the protein corona of nanocarriers in IgG‐enriched blood plasma resulting in increased cell uptake. This could be prevented by pre‐coating the nanocarriers with the “stealth” protein clusterin. Cover design by Stefan Schuhmacher.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2019-05-01 | Advanced Science |