0000000000038008

AUTHOR

Domenik Prozeller

showing 3 related works from this author

Protein Corona: Prevention of Dominant IgG Adsorption on Nanocarriers in IgG‐Enriched Blood Plasma by Clusterin Precoating (Adv. Sci. 10/2019)

2019

The development of nanocarriers for drug delivery is challenged by individual blood composition fluctuations. In article number 1802199, Svenja Morsbach and co‐workers report the accumulation of immunoglobulins in the protein corona of nanocarriers in IgG‐enriched blood plasma resulting in increased cell uptake. This could be prevented by pre‐coating the nanocarriers with the “stealth” protein clusterin. Cover design by Stefan Schuhmacher.

Back Coverstealth effectnanocarriersClusterinbiologyclusterinChemistryGeneral Chemical EngineeringGeneral EngineeringGeneral Physics and AstronomyMedicine (miscellaneous)Protein CoronaBiochemistry Genetics and Molecular Biology (miscellaneous)Molecular biologyImmunoglobulin Gimmunoglobulin Gprotein coronaAdsorptionBlood plasmabiology.proteinGeneral Materials ScienceNanocarriersAdvanced Science
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Prevention of Dominant IgG Adsorption on Nanocarriers in IgG‐Enriched Blood Plasma by Clusterin Precoating

2019

Abstract Nanocarriers for medical applications must work reliably within organisms, independent of the individual differences in the blood proteome. Variation in the blood proteome, such as immunoglobulin levels, is a result of environmental, nutrition, and constitution conditions. This variation, however, should not influence the behavior of nanocarriers in biological media. The composition of the protein corona is investigated to understand the influence varying immunoglobulin levels in the blood plasma have on the interactions with nanocarriers. Specifically, the composition of the nanocarriers' coronas is analyzed after incubation in plasma with normal or elevated immunoglobulin G (IgG)…

clusterinGeneral Chemical Engineeringmedia_common.quotation_subjectGeneral Physics and AstronomyMedicine (miscellaneous)Protein Corona02 engineering and technology010402 general chemistry01 natural sciencesBiochemistry Genetics and Molecular Biology (miscellaneous)Immunoglobulin Gimmunoglobulin Gprotein coronaBlood plasmaGeneral Materials ScienceReceptorInternalizationlcsh:Sciencemedia_commonstealth effectbiologyFull PapernanocarriersChemistryGeneral EngineeringFull Papers021001 nanoscience & nanotechnology0104 chemical sciencesIgG bindingBiophysicsbiology.proteinlcsh:QNanocarriersAntibody0210 nano-technologyAdvanced Science
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Controlling protein interactions in blood for effective liver immunosuppressive therapy by silica nanocapsules

2020

Immunosuppression with glucocorticoids is a common treatment for autoimmune liver diseases and after liver transplant, which is however associated with severe side-effects. Targeted delivery of glucocorticoids to inflammatory cells, e.g. liver macrophages and Kupffer cells, is a promising approach for minimizing side effects. Herein, we prepare core–shell silica nanocapsules (SiO2 NCs) via a sol–gel process confined in nanodroplets for targeted delivery of dexamethasone (DXM) for liver immunosuppressive therapy. DXM with concentrations up to 100 mg mL−1 in olive oil are encapsulated while encapsulation efficiency remains over 95% after 15 days. Internalization of NCs by non-parenchymal muri…

Apolipoprotein BCell SurvivalLiver cytologyPharmacologybehavioral disciplines and activitiesDexamethasoneNanocapsulesProinflammatory cytokine//purl.org/becyt/ford/1 [https]MiceDrug Delivery SystemsDrug StabilityNanocapsulesQuímica Coloidalmental disordersBlood plasma//purl.org/becyt/ford/1.4 [https]AnimalsHumansIMMUNOSUPPRESSIVE THERAPYTissue DistributionGeneral Materials ScienceColloidsImmunosuppression TherapybiologyClusterinChemistryCiencias QuímicasSILICA NANOCAPSULESSilicon DioxideBlood proteinsPROTEIN INTERACTIONSDEXAMETHASONELiverbiology.proteinPEGylationCytokinesCIENCIAS NATURALES Y EXACTASImmunosuppressive AgentsHeLa CellsNanoscale
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