6533b7cefe1ef96bd1257046

RESEARCH PRODUCT

Semaglutide reduces fat accumulation in the tongue: A randomized single-blind, pilot study

Simona FerjanAndrej JanežMojca JensterleAndrej VovkTadej BattelinoManfredi Rizzo

subject

Adultmedicine.medical_specialtyWaistEndocrinology Diabetes and MetabolismGlucagon-Like PeptidesAdipose tissuePilot ProjectsPlaceboGastroenterologyEndocrinologyDouble-Blind MethodTongueTongueInternal medicineInternal MedicinemedicineHumansSingle-Blind MethodObesityGlucagon like peptide-1 receptor Obesity PCOS Semaglutide Tongue fat Adult Double-Blind Method Female Glucagon-Like Peptides Humans Obesity Pilot Projects Single-Blind Method Adiposity TongueAdipositybusiness.industrySemaglutideGeneral Medicinemedicine.diseaseObesityPolycystic ovarymedicine.anatomical_structureFemalebusinessBody mass index

description

Abstract Aim We evaluated the effect of the latest GLP-1 RA semaglutide on tongue fat storage in obese women. Design. We conducted a randomized single-blind, pilot study. Methods Twenty-five obese women with polycystic ovary syndrome (PCOS) (33.7 ± 5.3 years, body mass index (BMI) 36.1 ± 3.9 kg/m2, mean ± SD) were randomized to semaglutide 1.0 mg or placebo for 16 weeks. We quantified tongue volume and its fat tissue and fat proportion by magnetic resonance imaging. Results Tongue fat tissue and fat proportion significantly reduced after semaglutide vs placebo (-1.94 ± 5.51 vs. + 3.12 ± 4.87 cm3, p = 0.022, and −0.02 ± 0.07 vs. 0.04 ± 0.06, p = 0.010, respectively). Correlation analysis revealed that these reductions were associated with those in body weight, BMI and waist circumference (p = 0.010 for all). Conclusions This is the first study confirming the beneficial effect of semaglutide on tongue structure in obese women with PCOS. Further studies are needed to assess the clinical importance of such findings.

yearjournalcountryeditionlanguage
2021-08-01
10.1016/j.diabres.2021.108935http://hdl.handle.net/10447/549465