6533b7cefe1ef96bd125709c

RESEARCH PRODUCT

Association between Serum Heat Shock Proteins and Gamma-Delta T Cells—An Outdated Clue or a New Direction in Searching for an Anticancer Strategy? A Short Report

Maciej NiedźwieckiPiotr TrzonkowskiFrancesco CappelloMagdalena Gorska-ponikowskaDorota Pawlik-gwozdeckaMaciej ZielińskiJustyna Sakowska

subject

Technologyacute lymphoblastic leukaemiaQH301-705.5LymphocyteCD3QC1-999Human leukocyte antigenBiologyFlow cytometryHeat shock proteinmedicineGeneral Materials ScienceBiology (General)InstrumentationChildhood allQD1-999Fluid Flow and Transfer Processesmedicine.diagnostic_testAcute lymphoblastic leukaemia Gamma-delta T cells Serum HSP90Process Chemistry and Technologyserum HSP90TPhysicsGeneral Engineeringgamma-delta T cellsEngineering (General). Civil engineering (General)Hsp90Computer Science ApplicationsChemistrymedicine.anatomical_structureImmunologybiology.proteinTA1-2040CD8

description

HSPs demonstrate a strong association with gamma-delta (γδ) T cells. Most of the studies regarding interactions between the parameters were conducted in the 1990s. Despite promising results, the concept of targeting γδ T cells by HSPs seems to be a forgotten direction due to potent non-peptidic phosphoantigens rather than HSPs have been found to be the essential stimulatory components for human γδ cells. Currently, with greater knowledge of lymphocyte diversity, and more accurate diagnostic methods, we decided to study the correlation once again in the neoplastic condition. Twenty-one children with newly diagnosed acute lymphoblastic leukaemia (ALL) were enrolled on the study. Serum HSP90 concentrations were evaluated by an enzyme-linked immunosorbent assay (ELISA), subsets of γδ T cells (CD3+ γδ, CD3+ γδ HLA/DR+, CD4+ γδ and CD8+ γδ) by flow cytometry. We have shown statistically relevant correlations between serum HSP90 and CD3+ HLA/DR+ γδ T cells in paediatric ALL at diagnosis (R = 0.53, p &lt

yearjournalcountryeditionlanguage
2021-08-09Applied Sciences
10.3390/app11167325https://www.mdpi.com/2076-3417/11/16/7325