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RESEARCH PRODUCT
Guillain-Barré syndrome after orthotopic liver transplantation: A clinical manifestation of immune reconstitution inflammatory syndrome?
Ioannis PetridisVincenzina Lo ReGianvincenzo SparaciaMariapina MilazzoAngelo LucaSalvatore GruttadauriaAlessandra MularoniGaetano BurgioSaša A. ŽIvkovićRiccardo Volpessubject
medicine.medical_treatmentLiver transplantationGuillain-Barre SyndromeTacrolimus030207 dermatology & venereal diseases03 medical and health sciences0302 clinical medicineImmune systemImmune reconstitution inflammatory syndromemedicineHumansImmune reconstitution inflammatory syndromeAcute demyelinating polyneuropathyImmunosuppression TherapyInflammationLiver transplantationGuillain-Barre syndromebusiness.industryImmunosuppressionGeneral Medicinemedicine.diseaseGuillain-Barré syndromeTacrolimusPathophysiologyTacrolimuImmunologyAcute demyelinating polyneuropathy; Guillain-Barré syndrome; Immune reconstitution inflammatory syndrome; Liver transplantation; TacrolimusSurgeryFemaleNeurology (clinical)Complicationbusiness030217 neurology & neurosurgerydescription
Guillain-Barrè Syndrome, as part of the spectrum of dysimmune neuropathies, is unexpected to occur in immunocompromised hosts. We describe a clinical case of Guillain-Barrè syndrome, occurred a few weeks after a liver transplant, and we postulate that our case would satisfy all requirements to explain this peripheral nervous system complication as a clinical manifestation of an Immune reconstitution inflammatory syndrome. In this setting of liver transplantation, complicated by potentially multiple infective triggers, reduction of immunosuppression and reversal of pathogen-induced immunosuppression, through antimicrobial therapy, may have led to pro-inflammatory response. The pro-inflammatory pattern would have sustained the pathophysiologic mechanism of this immune neuropathy.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2018-01-01 |