6533b7cefe1ef96bd125718b

RESEARCH PRODUCT

The Cumulative Effect of Transient Synchrony States on Motor Performance in Parkinson's Disease.

Erlick A. C. PereiraAbteen MostofiAlek PogosyanAlek PogosyanManuel BangeFlavie TorrecillosFlavie TorrecillosKeyoumars AshkanGerd TinkhauserGerd TinkhauserGerd TinkhauserSergiu GroppaMuthuraman MuthuramanPetra FischerPetra FischerMartin GlaserHuiling TanHuiling TanHarutomo HasegawaPeter BrownPeter Brown

subject

0301 basic medicineMaleParkinson's diseaseBehavioral/CognitiveParkinson's diseaseDeep Brain StimulationElectroencephalography Phase Synchronization610 Medicine & healthLocal field potentialHypokinesialocal field potentialsBasal Ganglia03 medical and health sciencesBursting0302 clinical medicineSubthalamic NucleusBasal gangliaMedicineHumansBeta (finance)610 Medicine & healthCumulative effectResearch ArticlesAgedCued speechbeta oscillationsbusiness.industryGeneral NeuroscienceParkinson DiseaseMiddle Agedmedicine.diseaseSubthalamic nucleus030104 developmental biologyFemaleCuesbusinessBeta RhythmNeuroscience030217 neurology & neurosurgeryPhotic StimulationPsychomotor Performance

description

Bursts of beta frequency band activity in the basal ganglia of patients with Parkinson's disease (PD) are associated with impaired motor performance. Here we test in human adults whether small variations in the timing of movement relative to beta bursts have a critical effect on movement velocity and whether the cumulative effects of multiple beta bursts, both locally and across networks, matter.

10.1523/jneurosci.1975-19.2019