6533b7cefe1ef96bd12571ba
RESEARCH PRODUCT
Clinical utility of novel biomarkers for cardiovascular disease risk stratification
Maurizio AvernaDavide Notosubject
medicine.medical_specialtySettore MED/09 - Medicina InternaDiseaseIndividual riskRisk AssessmentCoronary artery diseaseInternal MedicinemedicineHumansRisk factorIntensive care medicinebusiness.industryBiomarkerCardiovascular riskAtherosclerosismedicine.diseaseIntervention studiesSurgeryCardiovascular DiseasesEmergency MedicineDisease riskPredictive powerObservational studybusinessPredictive powerBiomarkersdescription
Over the past few decades, a number of coronary artery disease (CAD) and cardiovascular disease (CVD) risk factors have been identified. The predictive power of "conventional" risk factors have been validated by observational, prospective and intervention studies. Nevertheless, all attempts to exactly predict the individual risk for CAD have failed, biased by a large number of incorrectly risk-classified subjects. To improve cardiovascular (CV) risk prediction, a large number of genetic and/or non-genetic biomarkers have been discovered and tested against the "classical" risk factors for their power to predict CV risk. Only few of them had a significant improvement over the predictive models. In this paper, the most investigated biomarkers will be discussed and the evidence of their use as predictors of CV will be questioned.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2012-10-01 | Internal and Emergency Medicine |