6533b7cefe1ef96bd125720f
RESEARCH PRODUCT
Rugged Large Volume Injection for Sensitive Capillary LC-MS Environmental Monitoring
Sunniva Furre AmundsenElsa LundanesHanne Roberg-larsenDeniz DemirSilvija AbeleSilvija AbeleDiana DzabijevaVadims BartkevicsSteven Ray Wilsonsubject
Resolution (mass spectrometry)Capillary actionAnalytical chemistry02 engineering and technologycapillary LC01 natural scienceslaw.inventionlcsh:ChemistrylawLiquid chromatography–mass spectrometrySample preparationSolid phase extractionon-line solid phase extractionFiltrationOriginal ResearchDetection limitChromatographyChemistry010401 analytical chemistryGeneral ChemistryRepeatability021001 nanoscience & nanotechnology0104 chemical sciencespharmaceutical productsChemistrylcsh:QD1-999column switchinglarge volume injection0210 nano-technologydescription
A rugged and high throughput capillary column (cLC) LC-MS switching platform using large volume injection and on-line automatic filtration and filter back-flush (AFFL) solid phase extraction (SPE) for analysis of environmental water samples with minimal sample preparation is presented. Although narrow columns and on-line sample preparation are used in the platform, high ruggedness is achieved e.g. injection of 100 non-filtrated water samples would did not result in a pressure rise/clogging of the SPE/capillary columns (inner diameter 300 µm). In addition, satisfactory retention time stability and chromatographic resolution were also features of the system. The potential of the platform for environmental water samples was demonstrated with various pharmaceutical products, which had detection limits (LOD) in the 0.05 – 12.5 ng/L range. Between-day and within-day repeatability of selected analytes were < 20% RSD.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2017-08-28 | Frontiers in Chemistry |