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RESEARCH PRODUCT
Exploring a regulatory role for mast cells: 'MCregs'?
Carlo PucilloBarbara FrossiClaudio TripodoGiorgia Grisubject
InflammationEffectorMast cell; Regulatory cells; cell-cell crosstalkImmunologyRegulatory cellModels ImmunologicalAutoimmunityAdaptive ImmunityBiologybiochemical phenomena metabolism and nutritionAcquired immune systemT-Lymphocytes RegulatoryImmunity InnateClassical complement pathwaycell-cell crosstalkImmune systemRegulatory cellsNeoplasmsImmunologyImmune ToleranceMAST CELLAnimalsHumansImmunology and AllergyMast Cellsdescription
Regulatory cells can mould the fate of the immune response by direct suppression of specific subsets of effector cells, or by redirecting effectors against invading pathogens and infected or neoplastic cells. These functions have been classically, although not exclusively, ascribed to different subsets of T cells. Recently, mast cells have been shown to regulate physiological and pathological immune responses, and thus to act at the interface between innate and adaptive immunity assuming different functions and behaviors at discrete stages of the immune response. Here, we focus on these poorly defined, and sometimes apparently conflicting, functions of mast cells.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2010-01-01 |