6533b7cefe1ef96bd1257a01
RESEARCH PRODUCT
Oxidative burst inhibitory and cytotoxic amides and lignans from the stem bark of Fagara heitzii (Rutaceae)
Marie Aleth Lacaille-duboisLuc Meva'a MbazeJean Alexandre LadoJean Alexandre LadoRené RoyJean Duplex WansiJean Duplex WansiMuhammad Iqbal ChoudharyDavid Dako ChiozemMuhammad Ahmed MesaikTze Chieh ShiaoJean WandjiNorbert Sewaldsubject
MaleCytotoxicityChemical structurePhagocytosisPlant ScienceHorticultureHeterocyclic Compounds 2-RingBiochemistryAntioxidantsLignansInhibitory Concentration 50chemistry.chemical_compoundPhagocytosisCell Line TumorHumansImmunologic FactorsCytotoxic T cellFagara heitziiCytotoxicityRutaceaeMolecular BiologyRespiratory BurstLignanPlant StemsPlant ExtractsZymosanZymosanProstatic NeoplasmsBiological activityGeneral MedicineAntineoplastic Agents PhytogenicAmidesOxidative burstinhibitionRespiratory burstchemistryBiochemistryPlant BarkPhenylethanoidsdescription
Two amides, heitziamide A and heitziamide B and two phenylethanoids, heitziethanoid A and heitziethanoid B together with thirteen known compounds were isolated from F. heitzii (Letouzey). The structures of all compounds were established by spectroscopic analysis. Nine compounds were evaluated for oxidative burst inhibitory activity in a chemoluminescence assay and for cytotoxicity against PC-3 prostate cancer cells. All compounds exhibited a clear suppressive effect on phagocytosis response upon activation with serum opsonized zymosan at the range of IC50 = 2.0-6.5 mu M, but no cytotoxic effect was observed (IC50 > 100 mu M). (C) 2009 Elsevier Ltd. All rights reserved.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2009-05-30 | Phytochemistry |