Redox regulation of genome stability by effects on gene expression, epigenetic pathways and DNA damage/repair

6533b7cefe1ef96bd1257a62

RESEARCH PRODUCT

Redox regulation of genome stability by effects on gene expression, epigenetic pathways and DNA damage/repair

Agnes Görlach Yuliya Mikhed Andreas Daiber Ulla G. Knaus

subject

Genome instability Redox signaling RNA Untranslated Epigenetic regulation of neurogenesis DNA Repair HuR mRNA-binding protein in the 3′-untranslated region Clinical Biochemistry HDAC histone deacetylase Review Article AP-1 activator protein 1 Biochemistry Ape-1 apurinic/apyrimidinic endonuclease 1 GPx-1 glutathione peroxidase-1 Epigenesis Genetic Histones Trx thioredoxin PHD prolylhydroxylase BER base excision repair lcsh:QH301-705.5 HO-1 heme oxygenase-1 Epigenomics Genetics Regulation of gene expression Nox member of the NADPH oxidase family lcsh:R5-920 JmjC Jumonji C domain-containing histone demethylases HIF-1α hypoxia inducible factor-1α 5-hmC 5-hydroxymethylcytosine ddc:Cell biology MMP matrix metalloproteinase Grx glutaredoxin GAPDH glyceraldehyde-3-phosphate dehydrogenase Nrf2 nuclear factor erythroid related factor 2 DNA methylation Epigenetics lcsh:Medicine (General)Oxidation-Reduction Signal Transduction 5-mC 5-methylcytosine DNA repair DNA damage NF-κB nuclear factor-κB Biology Genomic Instability RNS reactive nitrogen species ROS reactive oxygen species NER nucleotide excision repair SOD superoxide dismutase OxyR transcription factor (hydrogen peroxide-inducible genes activator)Humans Epigenetics Organic Chemistry PETN pentaerithrityl tetranitrate Gene regulation Oxidative Stress DNMT DNA methyltransferase Gene Expression Regulation lcsh:Biology (General)AREs AU-rich elements HAT histone acetyltransferase Keap1 kelch-like ECH-associated protein 1 Biomarkers COPD chronic obstructive pulmonary disorder DNA Damage

description

Reactive oxygen and nitrogen species (e.g. H2O2, nitric oxide) confer redox regulation of essential cellular signaling pathways such as cell differentiation, proliferation, migration and apoptosis. In addition, classical regulation of gene expression or activity, including gene transcription to RNA followed by translation to the protein level, by transcription factors (e.g. NF-κB, HIF-1α) and mRNA binding proteins (e.g. GAPDH, HuR) is subject to redox regulation. This review will give an update of recent discoveries in this field, and specifically highlight the impact of reactive oxygen and nitrogen species on DNA repair systems that contribute to genomic stability. Emphasis will be placed on the emerging role of redox mechanisms regulating epigenetic pathways (e.g. miRNA, DNA methylation and histone modifications). By providing clinical correlations we discuss how oxidative stress can impact on gene regulation/activity and vise versa, how epigenetic processes, other gene regulatory mechanisms and DNA repair can influence the cellular redox state and contribute or prevent development or progression of disease.

year	journal	country	edition	language
2015-08-01	Redox Biology

10.1016/j.redox.2015.05.008 http://dx.doi.org/10.1016/j.redox.2015.05.008