Search results for "HuR"

showing 10 items of 938 documents

Insecticidal Activity and Synergistic Combinations of Ten Different Bt Toxins against Mythimna separata (Walker)

2018

The oriental armyworm (OAW), Mythimna separata (Walker), is a destructive pest of agricultural crops in Asia and Australia. Commercialized Bt crops have performed very well against their target pests

0301 basic medicineInsecticidesHealth Toxicology and MutagenesisBacterial ToxinsBacillus thuringiensislcsh:MedicineVip3 proteinMothsToxicologymedicine.disease_causeArticleMicrobiology03 medical and health sciencesMythimna separataBacillus thuringiensis<i>Bacillus thuringiensis</i>medicineAnimalsBioassayPotencyCry proteinbiologyToxinlcsh:Rfungifood and beveragesDrug Synergismbiology.organism_classification030104 developmental biologyCry1AcLarvaoriental armywormPEST analysisBacteriaToxins
researchProduct

Redox regulation of genome stability by effects on gene expression, epigenetic pathways and DNA damage/repair

2015

Reactive oxygen and nitrogen species (e.g. H2O2, nitric oxide) confer redox regulation of essential cellular signaling pathways such as cell differentiation, proliferation, migration and apoptosis. In addition, classical regulation of gene expression or activity, including gene transcription to RNA followed by translation to the protein level, by transcription factors (e.g. NF-κB, HIF-1α) and mRNA binding proteins (e.g. GAPDH, HuR) is subject to redox regulation. This review will give an update of recent discoveries in this field, and specifically highlight the impact of reactive oxygen and nitrogen species on DNA repair systems that contribute to genomic stability. Emphasis will be placed …

Genome instabilityRedox signalingRNA UntranslatedEpigenetic regulation of neurogenesisDNA RepairHuR mRNA-binding protein in the 3′-untranslated regionClinical BiochemistryHDAC histone deacetylaseReview ArticleAP-1 activator protein 1BiochemistryApe-1 apurinic/apyrimidinic endonuclease 1GPx-1 glutathione peroxidase-1Epigenesis GeneticHistonesTrx thioredoxinPHD prolylhydroxylaseBER base excision repairlcsh:QH301-705.5HO-1 heme oxygenase-1EpigenomicsGeneticsRegulation of gene expressionNox member of the NADPH oxidase familylcsh:R5-920JmjC Jumonji C domain-containing histone demethylasesHIF-1α hypoxia inducible factor-1α5-hmC 5-hydroxymethylcytosineddc:Cell biologyMMP matrix metalloproteinaseGrx glutaredoxinGAPDH glyceraldehyde-3-phosphate dehydrogenaseNrf2 nuclear factor erythroid related factor 2DNA methylationEpigeneticslcsh:Medicine (General)Oxidation-ReductionSignal Transduction5-mC 5-methylcytosineDNA repairDNA damageNF-κB nuclear factor-κBBiologyGenomic InstabilityRNS reactive nitrogen speciesROS reactive oxygen speciesNER nucleotide excision repairSOD superoxide dismutaseOxyR transcription factor (hydrogen peroxide-inducible genes activator)HumansEpigeneticsOrganic ChemistryPETN pentaerithrityl tetranitrateGene regulationOxidative StressDNMT DNA methyltransferaseGene Expression Regulationlcsh:Biology (General)AREs AU-rich elementsHAT histone acetyltransferaseKeap1 kelch-like ECH-associated protein 1BiomarkersCOPD chronic obstructive pulmonary disorderDNA DamageRedox Biology
researchProduct

Antimicrobial peptides from echinoderms as antibiofilm agents: a natural strategy to combat bacterial infections

2014

AbstractIncreased attention has been focused on marine invertebrates as a source of bioactive molecules for biomedical applications. Many bioactive molecules are part of the innate immune system. Some more recently isolated compounds, mainly from the sea urchin and the sea cucumber, are antimicrobial peptides (AMPs) active against Gram-positive and Gram-negative bacteria, and fungi. In this review we described the most recent studies on AMPs isolated from echinoderms. AMPs are small peptides (< 10 kDa) with cationic charge and amphipathic structure. Recently, it was demonstrated that in the coelomocyte lysates of Paracentrotus lividus and Holothuria tubulosa, AMPs possess activity against s…

Innate immune systembiologyPseudomonas aeruginosaAntimicrobial peptidesHolothuria tubulosaSettore BIO/05 - Zoologiabiology.organism_classificationmedicine.disease_causeParacentrotus lividusAntimicrobial peptides echinoderm Paracentrotus lividus Holothuria tubulosa antibiofilmMicrobiologySea cucumbermedicineAnimal Science and ZoologyCoelomocyteBacteria
researchProduct

Ks. Franz Urban (1832-1908) – ojciec cecylianizmu na ziemi kłodzkiej

2012

Wiek XIX, a zwłaszcza jego druga połowa, zaznaczył się w dziejach katolickiej muzyki kościelnej intensywnym ruchem odnowy (reforma cecyliańska). Ojcem tego ruchu na ziemi kłodzkiej był ks. Franz Urban, który już w 1869 roku założył w Lądku-Zdroju pierwsze koło cecyliańskie. W 1873 roku przekształciło się ono w Stowarzyszenie Cecyliańskie Hrabstwa Kłodzkiego i działało na rzecz poprawy stanu muzyki kościelnej aż do 1945 roku. W latach 1884–1902 funkcję prezesa tego związku pełnił ks. Franz Urban. Urodził się 6 stycznia 1832 roku w Wambierzycach. Po ukończeniu Gimnazjum Katolickiego w Kłodzku rozpoczął we Wrocławiu studia teologiczne. Święcenia kapłańskie przyjął 30 czerwca 1857 roku. Następn…

church musichrabstwo kłodzkiemuzyka kościelnaRadkówks. Franz UrbanRev. Franz UrbanCounty of KłodzkoCecilianismcecylianizmŚwidnickie Studia Teologiczne
researchProduct

Besprechung: Ch. Bakirtzis (Hrsg.), Mosaics of Thessaloniki. 4th-14th century, Athens 2012.

2014

Ch. Bakirtzis (Hrsg.), Mosaics of Thessaloniki. 4th-14th century, Athens 2012, 359 S. + 395 Abb. ISBN 978-960-6878-36-7

Historylcsh:History (General) and history of Europemedia_common.quotation_subjectHosios Davidlcsh:D111-203Hagios Georgios (Rotunda)Thessaloniki Hagios Georgios (Rotunda) Hagios Demetrios Acheiropoietos Church Hosios David Hagia Sophia Church of the Holy Apostleslcsh:Medieval historyArtAncient historylcsh:History of Greecelcsh:DF10-951ThessalonikiWall and vault mosaicsChurch of the Holy Apostleslcsh:DHagia SophiaHagios DemetriosAcheiropoietos ChurchClassicsClassicsmedia_commonΒυζαντινά Σύμμεικτα
researchProduct

Naturally occurring hemolysins in the coelomic fluid of Holothuria polii delle chiaie (Echinodermata).

1979

Abstract The coelomic fluid of Holothuria polii D.Ch contains hemolytic activity against erythrocytes of several vertebrate species. The hemolytic potency depends upon calcium ion concentration and varies according to erythrocyte source and cell number in the reaction mixture. Absorption experiments with formalinized rabbit erythrocytes suggest that hemolytic activity is not specific. Its heat lability, water insolubility at low pH values, and sensitivity to proteolytic enzymes suggest that hemolytic activity resides in protein molecules. The activity, maximal in alkaline media, appears to depend up time and temperature.

ErythrocytesCations DivalentSea CucumbersImmunologyDose-Response Relationship Immunologicchemistry.chemical_elementCalciumHemolysisHemolysin ProteinsPotencyAnimalsbiologyLabilityProteolytic enzymesTemperatureHemolysinExudates and TransudatesHydrogen-Ion Concentrationbiology.organism_classificationKineticschemistryBiochemistryCoelomAbsorption (chemistry)HolothuriaDevelopmental BiologyEchinodermataDevelopmental and comparative immunology
researchProduct

Oltre la ricerca del Graal, il divenire del mito

2014

A mythologist's study of the Graal cultural tradition. Using Francesco Zambon's recent Metamorfosi del Graal as his starting point, the author undertakes an analysis on the importance of the Graal in Western mystical, philosophical and literary traditions throughout time, from the impact of the medieval Graal stories on the matière de Bretagne and beyond (Troyes, Boron), to the appeal of this myth in modern times, including its occurrence on Richard Wagner, Martin Heidegger, Simone Weil, Italo Calvino and Umberto Eco.

UNESCO::CIENCIAS DE LAS ARTES Y LAS LETRASHistoryLiterature and Literary TheoryFilologíasmedia_common.quotation_subjectCultural traditionOtras filologías modernasArtMythologyMyths; Grail; matière de Bretagne; Arthurian myths; mythologies; gnoseology; philosophical traditions; imaginary; literary sources; religions; Perceval; Galahad; Joseph of Arimathea; Chrétien de Troyes; Robert de Boron:CIENCIAS DE LAS ARTES Y LAS LETRAS [UNESCO]HumanitiesMysticismThe Imaginarymedia_commonMagnificat Cultura i Literatura Medievals
researchProduct

Functional significance of membrane associated proteolysis in the toxicity of Bacillus thuringiensis Cry3Aa toxin against Colorado potato beetle.

2012

Abstract Bacillus thuringiensis Cry toxins are widely used as biocontrol agents in bioinsecticides and transgenic plants. In the three domain-Cry toxins, domain II has been identified as an important determinant of their highly specific activity against insects. In this work, we assessed the role in membrane associated proteolysis and toxicity in Colorado potato beetle (CPB) of a previously reported ADAM recognition motif present in Cry3Aa toxin domain II. We used site-directed mutagenesis to modify the Bacillus thuringiensis cry3A gene in amino acid residues 344, 346, 347, 351 and 353 of the ADAM recognition motif in Cry3Aa toxin. Cry3Aa toxin mutants displayed decreased toxicity when comp…

ProteasesColoradoProteolysisMutantBacillus thuringiensisToxicologymedicine.disease_causeMicrobiologyHemolysin ProteinsRecognition sequenceBacterial ProteinsBacillus thuringiensismedicineAnimalsAmino Acid SequencePest Control BiologicalCells Culturedbiologymedicine.diagnostic_testBacillus thuringiensis ToxinsMicrovilliToxinfungiColorado potato beetleWild typeSequence Analysis DNAbiology.organism_classificationColeopteraEndotoxinsBiochemistryProteolysisMutagenesis Site-DirectedToxicon : official journal of the International Society on Toxinology
researchProduct

Wkład ks. prof. Alojzego Kleina (1934–2002) w recepcję uzgodnień katolicko-reformowanych

2017

Artykuł przedstawia postać ks. prof. Alojzego Kleina (1934–2002), wieloletniego dyrektora Instytutu Ekumenicznego im. J.A. Möhlera w Paderborn, mającego wielkie zasługi w rozwoju ruchu ekumenicznego ze strony Kościoła katolickiego. W opracowaniu ukazano jedynie mały wycinek jego dorobku naukowego – wkład w recepcję uzgodnień katolicko reformowanych. Skoncentrowano się na dwóch fazach tegoż dialogu: fazie dialogu chrystologicznego i fazie dialogu eklezjologicznego. Końcowa część syntetycznie zbiera wyniki badań i formułuje wnioski.

dialogreceptionAlojzy KleindialoguearrangementSobór Watykański IIThe Second Vatican CouncilKościoły reformowaneReformed ChurchesKościół katolickirecepcjauzgodnienieCatholic ChurchPrzegląd Piśmiennictwa Teologicznego
researchProduct

Evolutionary relationships, biogeography and morphological characters of Glinus (Molluginaceae), with special emphasis on the genus composition in Su…

2021

Glinus is a small genus of Molluginaceae with 8–10 species mostly distributed in the tropics of the World. Its composition and evolutionary relationships were poorly studied. A new molecular phylogeny constructed here using nuclear (ITS) and chloroplast (rbcL, trnK-matK) markers confirmed the monophyly of the genus. Based on ITS analysis, the following well-supported lineages are present within Glinus: the G. bainesii lineage is recovered as sister to the remainder of the genus followed by G. oppositifolius. Three other clades are: G. hirtus with G. orygioides; G. radiatus and G. lotoides; the latter is represented by a sample from North America, and G. zambesiacus as sister to G. setifloru…

0106 biological sciencesMolluginaceaeEvolutionary biologyPlant Scienceбиогеография01 natural sciencesMonophylyGenusPlantaeGlinusNomenclatureMolecular systematicsMonograph0303 health sciencesFloristics &amp; DistributionSub-Saharan AfricaNomenclatureмолекулярная филогенияMollugoBiogeography1181 Ecology evolutionary biologyMolecular phylogeneticsTaxonomy (biology)Identification keyPHYLOGENYАфрикаBiologyCARYOPHYLLALES010603 evolutionary biologyMagnoliopsida03 medical and health sciencesGlinus lotoidesтаксономическая ревизияBotanyBiodiversity &amp; Conservationmolecular phylogenyEcology Evolution Behavior and SystematicsTaxonomy030304 developmental biologyWorldBotanyMacarthuriaceae15. Life on land11831 Plant biologybiology.organism_classificationtaxonomic revisionTracheophytaGlinusQK1-989AfricaмоллюгиновыеPhytoKeys
researchProduct