Amyloid in Alzheimer’s Disease: Guilty Beyond Reasonable Doubt?

6533b7cefe1ef96bd1257b0b

RESEARCH PRODUCT

Amyloid in Alzheimer’s Disease: Guilty Beyond Reasonable Doubt?

subject

0301 basic medicine Pharmacology Amyloid Reasonable doubt Amyloid pathology Amyloid Amyloid β Disease Toxicology 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Alzheimer Disease Animals Humans Amyloid cascade Psychology Neuroscience 030217 neurology & neurosurgery

description

Recently failed antiamyloidogenic trials call for an objective reassessment of the dominating amyloid cascade hypothesis of Alzheimer's disease (AD). Ongoing efforts focusing on amyloid β protein (Aβ), its deposition, and its removal need to be complemented by more intensive research in new directions. Those may either integrate amyloid pathology or will propose pathogenetic routes independent of Aβ in the search for the causes of AD.

year	journal	country	edition	language
2017-10-01	Trends in Pharmacological Sciences

https://doi.org/10.1016/j.tips.2017.07.002

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