6533b7cffe1ef96bd1257ca9
RESEARCH PRODUCT
Controlled Transdermal Release of Antioxidant Ferulate by a Porous Sc(III) MOF
Ross S. ForganMario Alberto Pérez-díazPaulo G. M. MileoEnrique LimaGerardo Leyva-gómezGénesis Osorio-toribioJavier Aguila-rosasJavier Aguila-rosasJonathan J. MagañaIsabel Abánades LázaroIsabel Abánades LázaroGuillaume MaurinRoberto Sánchez-sánchezIlich A. IbarraJ. Antonio ZárateJ. Antonio ZárateMiriam De J. Velásquez-hernándezsubject
0301 basic medicineAntioxidantmedicine.medical_treatmentHuman skin02 engineering and technologyArticleInorganic Chemistry03 medical and health sciencesmedicine[CHIM]Chemical Scienceslcsh:ScienceComputingMilieux_MISCELLANEOUSTransdermalMultidisciplinaryintegumentary systemChemistry021001 nanoscience & nanotechnologyBiocompatible materialControlled releaseCombinatorial chemistry3. Good healthChemistry030104 developmental biologyDrug deliveryMedicinelcsh:Q0210 nano-technologyDrug carrierMaterials Structuredescription
Summary The Sc(III) MOF-type MFM-300(Sc) is demonstrated in this study to be stable under physiological conditions (PBS), biocompatible (to human skin cells), and an efficient drug carrier for the long-term controlled release (through human skin) of antioxidant ferulate. MFM-300(Sc) also preserves the antioxidant pharmacological effects of ferulate while enhancing the bio-preservation of dermal skin fibroblasts, during the delivery process. These discoveries pave the way toward the extended use of Sc(III)-based MOFs as drug delivery systems (DDSs).
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2020-06-01 |