6533b7cffe1ef96bd1257d3b
RESEARCH PRODUCT
Alterations in speech and voice in patients with mucopolysaccharidoses.
Todsaporn NakaratAnnerose KeilmannChristina LampeAnne K Läßigsubject
AdultMalemedicine.medical_specialtyTime FactorsAdolescentVoice QualityMucopolysaccharidosisSigns and symptomsAudiologySpeech AcousticsSpeech and HearingYoung AdultSex FactorsArts and Humanities (miscellaneous)PhonationSpeech Production MeasurementmedicineHumansIn patientChildHoarsenessVoice Disordersbusiness.industryVoice-onset timeEnzyme replacement therapyAcousticsMiddle AgedMucopolysaccharidosesLPN and LVNVoice productionmedicine.diseaseHoarse voiceCase-Control StudiesChild PreschoolVoiceAudiometry Pure-ToneFemalemedicine.symptombusinessdescription
The mucopolysaccharidoses are a group of lysosomal disorders characterized by abnormal accumulation of glycosaminoglycans within cell lysosomes leading to a variety of signs and symptoms including alterations in speech and voice production. These changes were analysed in 44 patients with mucopolysaccharidosis (MPS) types I, II, and VI using standardized protocols. Compared to healthy individuals the diadochokinetic rate for the fast repetition of syllables was slower and more irregular, the voice-onset time for the voiceless consonant /p/ was shorter, and most patients had a hoarse voice. The fundamental frequency (F0) of sustained spoken vowels was in the normal range for most women and children with MPS, but adult males with MPS had a higher F0 than healthy men.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2013-03-23 | Logopedics, phoniatrics, vocology |