6533b7cffe1ef96bd1258260

RESEARCH PRODUCT

ChemInform Abstract: Chemoenzymatic-Chemical Synthesis of a (2-3)-Sialyl T Threonine Building Block and Its Application to the Synthesis of the N-Terminal Sequence of Leukemia-Associated Leukosialin (CD 43).

Andreas LieseNicole BézayHorst KunzGregor Dudziak

subject

LeukemiaStereochemistryChemistryBlock (permutation group theory)medicineSequence (biology)General MedicineThreonineLeukosialinCarbohydratemedicine.diseaseChemical synthesis

description

Protection of all functional groups of the carbohydrate portion of the chemoenzymatically synthesized sialyl T threonine ester 1 (R=R1 =H, R2 =tBu, Fmoc=9-fluorenylmethoxycarbonyl) and subsequent acidolysis of the tert-butyl ester afforded the building block 2 (R=Ac, R1 =Me, R2 =H). The latter is a useful tool in the solid-phase synthesis of the N-terminal sequence 3 of the leukemia-associated leukosialin.

https://doi.org/10.1002/chin.200142231