P-69TLR4 ELIMINATION PREVENTS LONG-LASTING ETHANOL EFFECTS ON COCAINE-INDUCED CONDITIONED PLACE PREFERENCE IN ADOLESCENT MICE

6533b7cffe1ef96bd12582ea

RESEARCH PRODUCT

P-69TLR4 ELIMINATION PREVENTS LONG-LASTING ETHANOL EFFECTS ON COCAINE-INDUCED CONDITIONED PLACE PREFERENCE IN ADOLESCENT MICE

María A. Aguilar Marta Rodríguez-arias Sandra Montagud-romero Maricarmen Blanco-gandía José Miñarro Consuelo Guerri María Pascual

subject

Long lasting Ethanol Ethanol treatment business.industry General Medicine Receptor-mediated endocytosis Brain damage Pharmacology Conditioned place preference chemistry.chemical_compound chemistry TLR4 Medicine medicine.symptom business Receptor

description

Our previous studies indicated that binge-like ethanol treatment in adolescent rats induces an increase in the conditioned rewarding effects of cocaine. Ethanol induces the production of cytokines and inflammatory mediators, that cause brain damage by activating the toll-like receptor 4 (TLR4) signaling response. To test if these receptor mediated the observed increased in cocaine-induced conditioned …

year	journal	country	edition	language
2015-09-01	Alcohol and Alcoholism

https://doi.org/10.1093/alcalc/agv080.69

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