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RESEARCH PRODUCT
Les anti-agrégants plaquettaires au cours du syndrome coronarien aigu. Données des grandes études
Yves CottinIsabelle L’huillierCarole RichardLuc LorgisMarianne ZellerAurélie GudjoncikPhilippe Buffetsubject
medicine.medical_specialtyAspirinAcute coronary syndromePrasugrelThienopyridinebusiness.industryClopidogrelmedicine.diseaseSurgeryClinical trialmedicineMedical prescriptionCardiology and Cardiovascular MedicineIntensive care medicinebusinessTicagrelormedicine.drugdescription
Cardiovascular disease is the leading cause of early death and morbidity in developed countries and is becoming a growing problem in many developing countries. Currently, anti-coagulants play a major role in the management of the acute phase in association or not with reperfusion strategies. The combination of clopidogrel and aspirin, in accordance with the results of large randomized trials, is the treatment of reference. However two new drugs, a thienopyridine (prasugrel), and a cyclo-pentyl-triazolo-pyridine (ticagrelor) have shown their interest in major studies in comparison with clopidogrel. As a result, several effective P2Y12 receptor antagonist anti-platelet agents are now available in the therapeutic arsenal, and the cardiologist have to tailored the best drug scheme according the balance between the risk of hemorrhage and the benefits with regard to the ischemia to determine the optimal prescription for every patient.
year | journal | country | edition | language |
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2010-12-01 | Annales de Cardiologie et d'Angéiologie |