6533b7cffe1ef96bd1258390

RESEARCH PRODUCT

Depressed Prostaglandin Release from Peritoneal Cells Induced by a T Cell Adjuvant, Lentinan

J. HamuroD. GemsaW. GrimmMartin RöllinghoffHermann WagnerM. Seitz

subject

chemistry.chemical_classificationmedicine.medical_specialtymedicine.medical_treatmentT cellLentinanProstaglandinGeneral MedicineImmunopotentiatorPharmacologyPolysaccharidechemistry.chemical_compoundmedicine.anatomical_structureImmune systemEndocrinologychemistryInternal medicinePeritoneal exudatemedicinelipids (amino acids peptides and proteins)Adjuvant

description

Abstract PGE and PGF release from peritoneal exudate cells was studied in mice after injection with two s (1–3) glucans, the antitumor active lentinan and the inactive pachyman. 4 days after injection of both polysaccharides, the spontaneous and phagocytosis-induced PGE and PGF release was markedly suppressed. However, only the immunopotentiator lentinan induced peritoneal exudate cells which exhibited a longer lasting diminished PG release. The data suggest that the T cell adjuvant lentinan may potentiate cellular immune responses by reducing synthesis of immune suppressive prostaglandins from peritoneal exudate cells.

yearjournalcountryeditionlanguage
1979-01-01Zeitschrift für Immunitätsforschung: Immunobiology
https://doi.org/10.1016/s0340-904x(79)80007-x