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RESEARCH PRODUCT
Synthesis of a MUC1-glycopeptide-BSA conjugate vaccine bearing the 3'-deoxy-3'-fluoro-Thomsen-Friedenreich antigen.
Manuel JohannesAnja Hoffmann-rödersubject
digestive systemCatalysisMiceAntigenConjugate vaccineMaterials ChemistryAnimalsAntigens Tumor-Associated Carbohydrateskin and connective tissue diseasesneoplasmsMUC1Vaccines ConjugatebiologyThomsen-Friedenreich AntigenChemistryMucin-1Metals and AlloysGlycopeptidesSerum Albumin BovineGeneral ChemistryMolecular biologybiological factorsdigestive system diseasesGlycopeptideSurfaces Coatings and FilmsElectronic Optical and Magnetic MaterialsCeramics and Compositesbiology.proteinCattleAntibodydescription
A novel MUC1-glycopeptide–BSA conjugate vaccine with a specifically fluorinated Thomsen–Friedenreich antigen side chain at Thr6 was prepared. Preliminary immunological experiments reveal specific binding of the tumor-associated glycopeptide antigen analog by anti-MUC1-mouse antibodies.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2011-08-06 | Chemical communications (Cambridge, England) |