6533b7cffe1ef96bd125842c

RESEARCH PRODUCT

Impairment of learning and memory performances induced by BPA Evidences from the literature of a MoA mediated through an ED

Sakina Mhaouty-kodjaCécile ChevrierHenri SchroederElodie PasquierLuc P. BelzuncesMarie-chantal Canivenc

subject

0301 basic medicineNervous systemNervous systemendocrine systemmedicine.drug_classEndocrine disruptionBiologyEndocrine DisruptorsBiochemistryLearning and memory03 medical and health scienceschemistry.chemical_compound0302 clinical medicineEndocrinologyMESH: PhenolsBisphenol APhenolsMemorymedicineMESH: Benzhydryl CompoundsAnimalsHumansBenzhydryl compoundsMESH: MemoryBenzhydryl CompoundsMode of actionMolecular BiologyBehavior Animalurogenital systemBrainCognitionEnvironmental exposureEnvironmental ExposureReceptor antagonistMESH: Endocrine Disruptors030104 developmental biologymedicine.anatomical_structurechemistrySynaptic plasticity[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologieSignal transductionNeuroscience030217 neurology & neurosurgeryhormones hormone substitutes and hormone antagonists

description

International audience; Many rodent studies and a few non-human primate data report impairments of spatial and non-spatial memory induced by exposure to bisphenol A (BPA), which are associated with neural modifications, particularly in processes involved in synaptic plasticity. BPA-induced alterations involve disruption of the estrogenic pathway as established by reversal of BPA-induced effects with estrogenic receptor antagonist or by interference of BPA with administered estradiol in ovariectomized animals. Sex differences in hormonal impregnation during critical periods of development and their influence on maturation of learning and memory processes may explain the sexual dimorphism observed in BPA-induced effects in some studies. Altogether, these data highly support the plausibility that alteration of learning and memory and synaptic plasticity by BPA is essentially mediated by disturbance of the estrogenic pathways. As memory function in humans involves similar signaling pathways, this mode of action of BPA has the potential to alter human cognitive abilities.

10.1016/j.mce.2018.03.017https://hal-univ-rennes1.archives-ouvertes.fr/hal-01864336