6533b7cffe1ef96bd12584b6
RESEARCH PRODUCT
Glycyrrhetinic Acid Reverses the Lipopolysaccharide-Induced Hypocontractility to Noradrenaline in Rat Aorta: Implications to Septic Shock
Jean-claude StocletAndrei L. KleschyovAndrei L. KleschyovPetr G. AparinBernard MullerBernard Mullersubject
LipopolysaccharidesMaleLipopolysaccharideArgininePharmacologychemistry.chemical_compoundNorepinephrinemedicine.arteryActive componentNo synthaseGlycyrrhizaMedicineAnimalsEnzyme InhibitorsRats WistarAortaPharmacologyVascular contractilityAortabusiness.industrySeptic shocklcsh:RM1-950medicine.diseaseShock SepticEpr spin trappinglcsh:Therapeutics. PharmacologychemistryBiochemistryVasoconstrictionMolecular MedicineGlycyrrhetinic AcidNitric Oxide SynthasebusinessPhytotherapydescription
Abstract.: Septic shock and associated vascular hyporeactivity to vasoconstrictor agonists remain a major problem of critical care medicine. Here we report that glycyrrhetinic acid (GA), the active component of licorice, effectively restores vascular contractility in the model of lipopolysaccharide (LPS)-treated rat aorta. GA was as effective as the NO synthase inhibitor NG-nitroarginine methylester. GA did not affect the vascular NO levels (measured by EPR spin trapping) and relaxations to l-arginine in LPS-treated rings as well as relaxation to S-nitroso-Nacetylpenicillamine in control rings. Thus, GA may represent an interesting alternative to NO synthase inhibitors in sepsis-associated vascular dysfunction. Keywords:: glycyrrhetinic acid, lipopolysaccharide, septic shock
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2014-08-22 | Journal of Pharmacological Sciences |