6533b7cffe1ef96bd1258529
RESEARCH PRODUCT
Estimation of Solute-Stationary Phase and Solute-Mobile Phase Interactions in the Presence of Ionic Liquids
Maria Jose Ruiz-angelsubject
Inorganic chemistryRPLCIonic bondingFiltration and Separation01 natural sciencesAnalytical ChemistryIonlcsh:Chemistryionic liquidschemistry.chemical_compoundAdsorptionPhase (matter)Triethylaminepeak shape010405 organic chemistry010401 analytical chemistryCationic polymerizationchemical equilibrialcsh:QC1-9990104 chemical sciencesSilanolbasic drugslcsh:QD1-999chemistryIonic liquidlcsh:Physicsdescription
The presence of free silanols on alkyl-bonded reversed-phase stationary phases is responsible for broad and asymmetrical peaks when basic drugs are chromatographed with conventional octadecylsilane (C18) columns due to ionic interactions. In the last few years, ionic liquids (ILs) have attracted attention to reduce this undesirable silanol activity. ILs should be considered as dual modifiers (with a cationic and anionic character), which means that both cations and anions are able to adsorb on the stationary phase, creating a positively or negatively charged layer, depending on the relative adsorption. The accessibility of basic compounds to the silanols is prevented by both the IL cation and anion, improving the peak profiles. A comparative study of the performance of six imidazolium-based ILs, differing in their cation/anions, as modifiers of the chromatographic behavior of a group of ten &beta
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2019-08-13 | Separations |