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RESEARCH PRODUCT
Left, Right, or Both? On the Configuration of the Phenanthroindolizidine Alkaloid Tylophorine from Tylophora indica
Theodor Edmund PeezTill OpatzAlexander Stoyesubject
PharmacologyMolecular StructureChemistryAlkaloidOrganic ChemistryIndolizinesPharmaceutical ScienceTylophoraPhenanthrenesHigh-performance liquid chromatographyLevorotatoryAnalytical ChemistryChiral column chromatographyAlkaloidsTylophora indicaComplementary and alternative medicineDrug DiscoveryMolecular MedicineOrganic chemistryRacemic mixturePhenanthrolinesdescription
The alkaloid (-)-tylophorine was isolated from a sample of Tylophora indica, and the crude extract was analyzed by HPLC/MS(n) and chiral HPLC/MS. While the literature states that the naturally occurring form of this alkaloid is the R-enantiomer and that its S-antipode is usually not found in nature, we confirmed the hypothesis of Govindachari and Nagarajan that natural levorotatory tylophorine is indeed a nearly racemic mixture with a slight excess of the R-enantiomer.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2013-01-31 | Journal of Natural Products |