6533b7cffe1ef96bd12585c4

RESEARCH PRODUCT

Spinal Endocannabinoids and CB 1 Receptors Mediate C-Fiber–Induced Heterosynaptic Pain Sensitization

Hanns Ulrich ZeilhoferHanns Ulrich ZeilhoferRita NyilasJ. FilitzRobert WitschiRobert WitschiGuangchen JiWolfgang KoppertAko KatoAko KatoTamás F. FreundMasahiko WatanabeVolker NeugebauerBeat LutzIstván KatonaHoracio VanegasJürgen SchüttlerAlejandro J. Pernia-andradeGiovanni Marsicano

subject

AdultMaleInterneuronPainMice TransgenicNeurotransmissionInhibitory postsynaptic potentialSynaptic TransmissionArticleRats Sprague-DawleyMiceYoung AdultPiperidinesReceptor Cannabinoid CB1InterneuronsCannabinoid Receptor ModulatorsmedicineAnimalsHumansPosterior Horn CellNerve Fibers UnmyelinatedMultidisciplinaryExcitatory Postsynaptic PotentialsNeural InhibitionAnatomySpinal cordElectric StimulationRatsMice Inbred C57BLPosterior Horn Cellsmedicine.anatomical_structureNociceptionInhibitory Postsynaptic PotentialsSpinal Cordnervous systemHyperalgesiaHyperalgesiaNeuropathic painPyrazolesFemaleRimonabantmedicine.symptomNeurosciencepsychological phenomena and processesEndocannabinoids

description

Plastic Pain Perception Drugs and endocannabinoids acting on cannabinoid (CB) receptors have potential in the treatment of certain types of pain. In the spinal cord they are believed to suppress nociception, the perception of pain and noxious stimuli. Pernia-Andrade et al. (p. 760 ) now find that endocannabinoids, which are released in spinal cord by noxious stimulation, may promote rather than inhibit nociception by acting on CB1 receptors. Endocannabinoids not only depress transmission at excitatory synapses in the spinal cord, but also block the release of inhibitory neurotransmitters, thereby facilitating nociception.

yearjournalcountryeditionlanguage
2009-08-08Science
https://doi.org/10.1126/science.1171870