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RESEARCH PRODUCT

IL-12 family members in experimental colitis

Markus F. Neurath

subject

EffectorT-Lymphocytesmedicine.medical_treatmentImmunologyInterleukinMaster regulatorExperimental colitishemic and immune systemsEBI3BiologyColitisInflammatory Bowel DiseasesInterleukin-12CytokineIntestinal inflammationImmunologyInterleukin 12medicineAnimalsHumansImmunology and AllergySignal Transduction

description

Interleukin (IL)-12 p35/p40 is a heterodimeric cytokine that plays an important role in T helper (Th) cell polarization and Th1 T-cell differentiation. Recent findings have shown that both p35 and p40 can form other cytokines with different proteins (IL-23: p19/p40; IL-35: p35/EBI3). Furthermore, the cytokine IL-27 (EBI3/p28) has been identified as a member of the IL-12 family. Here, we discuss the recent findings on the role of IL-12 family members in experimental colitis. In particular, the role of IL-23 as a master regulator of effector T-cell activation is highlighted. These findings have important implications for the design of new therapeutic approaches in chronic intestinal inflammation in humans.

yearjournalcountryeditionlanguage
2008-11-01Mucosal Immunology
https://doi.org/10.1038/mi.2008.45