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RESEARCH PRODUCT
Host—Guest Interactions Involving Cyclodextrins: Useful Complementary Insights Achieved by Polarimetry.
Renato NotoMichelangelo GruttadauriaFrancesca D'annaSerena RielaPaolo Lo Meosubject
ChemistryOrganic ChemistryDrug DiscoveryPolarimetryOrganic chemistrycyclodextrin binding abilityHost-guest interactionSettore CHIM/06 - Chimica OrganicaGeneral MedicineHost-guest interactions; cyclodextrin binding abilityBiological systemBiochemistryHost (network)description
Abstract By means of simple polarimetry, we studied the binding abilities of native α-, β-, and γ-cyclodextrins toward a group of suitably chosen model guests. We were able to get reliable estimations of the binding constants K, spread over a wide range (from 3.7 to 12,300 M−1), allowing us to carry on interesting comparisons. A comprehensive discussion of polarimetric data, and in particular a detailed analysis of the variations ΔΘ of molar optical activities consequent to inclusion, offered us the opportunity to get useful insights into the structure and dynamic behavior of host–guest complexes.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2007-01-01 | ChemInform |