6533b7cffe1ef96bd1258654

RESEARCH PRODUCT

Modulation of DNA binding by reversible metal-controlled molecular reorganizations of scorpiand-like ligands.

Carolina SerenaAntonio Garcia-españaSalvador BlascoM. Teresa AlbeldaClàudia Salat-canelaJuan C. FríasBegoña VerdejoEnrique García-españaMario InclánMaria Luisa Díaz

subject

Models MolecularCircular dichroismMacrocyclic CompoundsStereochemistryCell SurvivalDna interactionAntineoplastic AgentsNucleic Acid DenaturationBiochemistryCatalysisMetalchemistry.chemical_compoundColloid and Surface ChemistryCell Line TumorNeoplasmsAnimalsHumansBinding affinitiesCircular DichroismGeneral ChemistryDNAIntercalating AgentsDNA metabolismchemistryCell cultureMetalsvisual_artvisual_art.visual_art_mediumCattleSpectrophotometry UltravioletProtonsDNA

description

DNA interaction with scorpiand azamacrocycles has been achieved through modulation of their binding affinities. Studies performed with different experimental techniques provided evidence that pH or metal-driven molecular reorganizations of these ligands regulate their ability to interact with calf thymus DNA (ctDNA) through an intercalative mode. Interestingly enough, metal-driven molecular reorganizations serve to increase or decrease the biological activities of these compounds significantly.

yearjournalcountryeditionlanguage
2012-05-19Journal of the American Chemical Society
10.1021/ja300538shttps://pubmed.ncbi.nlm.nih.gov/22594493