6533b7cffe1ef96bd1258705
RESEARCH PRODUCT
Cellular therapies for the endometrium: An update
Carolina Von GrothusenCarlos SimónXavier SantamariaKristina Gemzell-danielssonSuzanna QueckbörnerLindsay C. Daviessubject
Infertilitybusiness.industryFemale infertilityCell- and Tissue-Based TherapyNeovascularization PhysiologicObstetrics and GynecologyAsherman's syndromeGynatresiaGeneral MedicineEndometriummedicine.diseaseBioinformaticsClinical trialCell therapyEndometriummedicine.anatomical_structuremedicineHumansFemaleFertility preservationbusinessMode of actionInfertility Femaledescription
An update on the current state of endometrial cell therapies in terms of cell types, mechanisms of action, delivery, safety, regulatory frameworks and future perspectives. This review focuses on clinical trials using angiogenesis-promoting therapies and stromal therapies piloted in the last 10 years for alleviating Asherman's syndrome and long-term infertility. All studies present promising preliminary results, indicating increased endometrial thickness and resumed menstruation. Further characterization of individual cell products, their mode of action and larger clinical trials will be essential to establishing cell therapy as a viable option for the treatment of infertility and fertility preservation.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2018-11-20 | Acta Obstetricia et Gynecologica Scandinavica |