6533b7cffe1ef96bd1258c7e

RESEARCH PRODUCT

Verlaufsbeobachtung des Kollagen- und Knochenstoffwechsels bei Patienten mit zementfreier Hüfttotalendoprothese*

Winfried PrellwitzA. MeurerA. EckardtM. GiesaJeffrey C. LotzJ. Heine

subject

Hip surgerymedicine.medical_specialtybusiness.industrymedicine.medical_treatmentUrologychemistry.chemical_elementOsteoarthritisCalciummedicine.diseaseArthroplastyOsseointegrationSurgeryBone remodelingchemistryOrthopedic surgeryMedicineOrthopedics and Sports MedicineSurgeryIn patientbusiness

description

Introduction This study investigated the influence of concentration and activity of several markers of the collagen and bone metabolism and their impact on ingrowth of non-cemented total hip arthroplasty. Methods 40 patients underwent an implantation of a ABG-prosthesis. Before surgery and 1, 2, 12 and 24 weeks after it serum concentrations of PICP, ICTP, IGF-1, ON, b-AP, Calcium, Phosphate, GPT and Creatinin were measured and a collagen ratio (CQ) was calculated. Results PICP decreased until 1st week, increased at 2nd week and decreased again after that time. ICTP increased significantly in 1st week, reached a maximum in 2nd week and decreased after that. b-AP decreased in 1st week but increased after that time. IGF-1 and ON decreased significantly after surgery but increased later. Calcium and Phosphate always showed normal values. CQ decreased in 1st week in males (45%) and females (60%), but increased later on. Conclusion These markers investigated made it possible to estimate the osteointegration of non-cemented total hip arthroplasty and confirm radiologic and histomorphometric results of the literature.

yearjournalcountryeditionlanguage
2008-03-18Zeitschrift für Orthopädie und ihre Grenzgebiete
https://doi.org/10.1055/s-2008-1067984