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RESEARCH PRODUCT
Microwave-Assisted Synthesis of Polysubstituted 4-Quinolones from Deprotonated α-Aminonitriles
Alexandra RomekTill Opatzsubject
chemistry.chemical_compoundDeprotonationMicrowave chemistryChemistryOrganic Chemistry4-quinolonesMicrowave irradiationCarboxylatePhysical and Theoretical ChemistryAlkylationPhotochemistryChemical synthesisMicrowavedescription
The α-alkylation of deprotonated N-aryl-α-aminonitriles with α-bromoesters furnishes intermediates that can be cyclized to 4-quinolones upon microwave irradiation. Alternatively, base-induced dehydrocyanation of the alkylation products furnishes enaminoesters, which can, for example, be converted into quinoline-3-carboxylates.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2010-09-01 | European Journal of Organic Chemistry |