0000000000073862

AUTHOR

Alexandra Romek

showing 2 related works from this author

Microwave-Assisted Synthesis of Polysubstituted 4-Quinolones from Deprotonated α-Aminonitriles

2010

The α-alkylation of deprotonated N-aryl-α-aminonitriles with α-bromoesters furnishes intermediates that can be cyclized to 4-quinolones upon microwave irradiation. Alternatively, base-induced dehydrocyanation of the alkylation products furnishes enaminoesters, which can, for example, be converted into quinoline-3-carboxylates.

chemistry.chemical_compoundDeprotonationMicrowave chemistryChemistryOrganic Chemistry4-quinolonesMicrowave irradiationCarboxylatePhysical and Theoretical ChemistryAlkylationPhotochemistryChemical synthesisMicrowaveEuropean Journal of Organic Chemistry
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ChemInform Abstract: Microwave-Assisted Synthesis of Polysubstituted 4-Quinolones from Deprotonated α-Aminonitriles.

2011

The α-alkylations of deprotonated Strecker products such as (I) or (V) give a series of intermediates such as (III), (VI), or (X), which undergo microwave-assisted HCN and EtOH eliminations leading to the title quinolones (IV), (VII)/(VIII), or (XI).

DeprotonationChemistry4-quinolonesGeneral MedicineMedicinal chemistryMicrowave assistedChemInform
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