6533b7cffe1ef96bd1258e47

RESEARCH PRODUCT

Screening of some rare endemic Italian plants for inhibitory activity on 5-lipoxygenase

José-maría PrietoJosé-luis RíosAmmar BaderIvano MorelliFrancesca Martini

subject

NeutrophilsLeukotriene B4PharmacognosyInhibitory postsynaptic potentialLeukotriene B4MicrobiologyThymus PlantLipoxygenasechemistry.chemical_compoundPlumbaginaceaeDrug DiscoveryBotanyAnimalsLipoxygenase InhibitorsGenistaRats WistarCytotoxicitySicilyCytisusPharmacologychemistry.chemical_classificationbiologyPlant ExtractsCytisusGeneral MedicinePlant Components Aerialbiology.organism_classificationRatsEnzymechemistryArachidonate 5-lipoxygenasebiology.protein

description

Abstract The extracts of four rare plants found on the islands of Sicily, Vulcano and Marettimo, Southern Italy, were screened for their inhibitory effect on the production of leukotriene B 4 by 5-lipoxygenase in intact cells. The methanol extracts of pods of Cytisus aeolicus and aerial parts of Thymus richardii were the most active extracts, inhibiting almost completely the leukotriene B 4 production at 200 and 50 μg/ml, respectively.

yearjournalcountryeditionlanguage
2003-11-27Fitoterapia
https://doi.org/10.1016/j.fitote.2005.07.003