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RESEARCH PRODUCT
RISK OF CARDIOVASCULAR DISEASE MORBIDITY AND MORTALITY IN FRAIL AND PRE-FRAIL OLDER ADULTS:RESULTS FROM A META-ANALYSIS AND EXPLORATORY META-REGRESSION ANALYSIS
Giorgio QuadriLuigi FontanaHélène AmievaEmanuele CeredaChristopher TzourioAlexis ElbazRoberto Alves LourençoTamara B. HarrisNicola VeroneseNicola VeroneseBrendon StubbsMarco SolmiPeter ManuClaudio MorettiMonika EicholzerSabine RohrmannAlessandro PolidoroValeria ScottiVirgílio Garcia MoreiraStefania MaggiFabrizio D'ascenzoJulien DumurgierClaudio LuchiniEnzo ManzatoTimo E. StrandbergGiuseppe SergiChristoph U. CorrellJuan Sanchissubject
GerontologyAging1303 Biochemistry030204 cardiovascular system & hematologyBiochemistry0302 clinical medicineRisk Factorscardiovascular diseasePrevalenceMedicine030212 general & internal medicineCardiovascular disease; Frailty; Meta-analysis; Aged; Frail Elderly; Humans; Prevalence; Risk Assessment; Risk Factors; Cardiovascular Diseases; Biotechnology; Biochemistry; Aging; Molecular Biology; NeurologyOXIDATIVE STRESSProspective cohort studyELDERLY-PATIENTSPOPULATIONeducation.field_of_studyFrailtyHazard ratioMENASSOCIATION16. Peace & justiceCardiovascular disease3. Good healthMIDLIFE OBESITYNeurologyCardiovascular DiseasesMeta-analysis1305 BiotechnologyRisk assessmentCardiovascular disease; Frailty; Meta-analysis; Aged; Frail Elderly; Humans; Prevalence; Risk Assessment; Risk Factors; Cardiovascular DiseasesBiotechnologymedicine.medical_specialtyWOMENS-HEALTHFrail ElderlyPopulationCardiovascular disease; Frailty; Meta-analysis; Biotechnology; Biochemistry; Aging; Molecular Biology; Neurology610 Medicine & healthfrailtyFrailty Cardiovascular disease Meta-analysisRisk AssessmentArticle03 medical and health sciences1302 AgingInternal medicine1312 Molecular BiologyHumansCORONARY-HEART-DISEASERisk factorFrailty cardiovascular disease meta-analysiseducationMolecular BiologyAgedbusiness.industryAGE FRAILTYOdds ratio10060 Epidemiology Biostatistics and Prevention Institute (EBPI)Confidence intervalmeta-analysisMeta-analysis3121 General medicine internal medicine and other clinical medicine2808 NeurologyFOLLOW-UPbusinessdescription
Frailty is common and associated with poorer outcomes in the elderly, but its role as potential cardiovascular disease (CVD) risk factor requires clarification. We thus aimed to meta-analytically evaluate the evidence of frailty and pre-frailty as risk factors for CVD. Two reviewers selected all studies comparing data about CVD prevalence or incidence rates between frail/pre-frail vs. robust. The association between frailty status and CVD in cross-sectional studies was explored by calculating and pooling crude and adjusted odds ratios (ORs)+/- 95% confidence intervals (CIs); the data from longitudinal studies were pooled using the adjusted hazard ratios (HRs). Eighteen cohorts with a total of 31,343 participants were meta-analyzed. Using estimates from 10 cross-sectional cohorts, both frailty and pre-frailty were associated with higher odds of CVD than robust participants. Longitudinal data were obtained from 6 prospective cohort studies. After a median follow-up of 4.4 years, we identified an increased risk for faster onset of any type CVD in the frail (HR= 1.70 [95%CI, 1.18-2.45]; I-2 = 66%) and pre-frail (HR= 1.23 [95%CI, 1.07-1.36]; I-2 = 67%) vs. robust groups. Similar results were apparent for time to CVD mortality in the frail and pre-frail groups. In conclusion, frailty and pre-frailty constitute addressable and independent risk factors for CVD in older adults. (C) 2017 Elsevier B.V. All rights reserved. Peer reviewed
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2017-05-01 |