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RESEARCH PRODUCT
Synergistic Anticancer Therapy by Ovalbumin Encapsulation-Enabled Tandem Reactive Oxygen Species Generation
Xiaojun PengMing XiaoKatharina LandfesterWen SunVolker MailänderVolker MailänderDaniel CrespyJiangli FanShuai JiangShuai Jiangsubject
inorganic chemicalsNanomedicines | Hot PaperOvalbuminmedicine.medical_treatmentRadicalsynergisticcisplatinPhotodynamic therapyAntineoplastic Agents010402 general chemistry01 natural sciencesCatalysisSuperoxide dismutasechemistry.chemical_compoundMicemedicineAnimalsHumansResearch Articleschemistry.chemical_classificationCisplatinReactive oxygen speciesOxidase testPhotosensitizing Agentsbiology010405 organic chemistryFenton reactionsDrug SynergismGeneral MedicineGeneral ChemistryhypoxicEndocytosis0104 chemical sciencesOvalbuminchemistryphotodynamic therapybiology.proteinBiophysicsMCF-7 CellsReactive Oxygen SpeciesNicotinamide adenine dinucleotide phosphatemedicine.drugResearch Articledescription
Abstract The anticancer efficacy of photodynamic therapy (PDT) is limited due to the hypoxic features of solid tumors. We report synergistic PDT/chemotherapy with integrated tandem Fenton reactions mediated by ovalbumin encapsulation for improved in vivo anticancer therapy via an enhanced reactive oxygen species (ROS) generation mechanism. O2 .− produced by the PDT is converted to H2O2 by superoxide dismutase, followed by the transformation of H2O2 to the highly toxic .OH via Fenton reactions by Fe2+ originating from the dissolution of co‐loaded Fe3O4 nanoparticles. The PDT process further facilitates the endosomal/lysosomal escape of the active agents and enhances their intracellular delivery to the nucleus—even for drug‐resistant cells. Cisplatin generates O2 .− in the presence of nicotinamide adenine dinucleotide phosphate oxidase and thereby improves the treatment efficiency by serving as an additional O2 .− source for production of .OH radicals. Improved anticancer efficiency is achieved under both hypoxic and normoxic conditions.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2020-09-15 |