6533b7cffe1ef96bd12594dd

RESEARCH PRODUCT

Networks in biological systems: An investigation of the Gene Ontology as an evolving network

Claudia CoronnelloMichele TumminelloSalvatore Micciche'Rosario Nunzio Mantegna

subject

Biological complexitySettore FIS/07 - Fisica Applicata(Beni Culturali Ambientali Biol.e Medicin)

description

Many biological systems can be described as networks where diFFerent elements interact, in order to perform biological processes. We introduce a network associated with the Gene Ontology. Specifically, we construct a correlation-based network where the vertices are the terms of the Gene Ontology and the link between each two terms is weighted on the basis of the number of genes that they have in common. We analyze a filtered network obtained from the correlation-based network and we characterize its evolution over different releases of the Gene Ontology.

10.1393/ncc/i2009-10386-7http://hdl.handle.net/10447/44551