6533b7cffe1ef96bd125984d
RESEARCH PRODUCT
Interleukin-7
P. K. E. TrinderMarkus Maeurersubject
Immune systemIn vivoImmunologymedicineLymphokineCancerInterleukinIn patientBiologymedicine.diseaseAcquired immune systemIn vitrodescription
This chapter discusses interleukin (IL)-7, which is an important lymphopoietin that plays a critical role in both B- and T-cell development. IL-7 promotes expansion of T lymphocytes exhibiting antigen-specific reactivity. IL-7 may be implemented to promote strong and effective immune responses against tumor cells, or directed against microbial or viral infections. It may also be useful in reconstituting an effective, and functional immune system after bone marrow transplantation, or helping to design novel strategies for immune reconstitution in patients with cancer or with HIV infection. IL-7 serves as the major growth and differentiation factor for both thymic and extrathymic development of γ∂ + T lymphocytes. IL-7 promotes immune effector functions in T lymphocytes, natural killer (NK) cells and mono-cytesmacrophages, and modulates the quantity and quality of immune responses in vitro and in vivo .
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2003-01-01 |