Minimization of dynamic effects in the evolution of dihydrofolate reductase

6533b7cffe1ef96bd1259932

RESEARCH PRODUCT

Minimization of dynamic effects in the evolution of dihydrofolate reductase

Iñaki Tuñón Louis Y. P. Luk Vicent Moliner J. Javier Ruiz-pernía Edric Joel Loveridge Rudolf Konrad Allemann Enas M. Behiry

subject

0301 basic medicine Stereochemistry 010402 general chemistry medicine.disease_cause enzyme catalysis 01 natural sciences Enzyme catalysis Catalysis 03 medical and health sciences dihydrofolate reductase Dihydrofolate reductase Escherichia coli medicine QD dynamic effects Escherichia coli chemistry.chemical_classification 030102 biochemistry & molecular biology biology Thermophile fungi food and beverages General Chemistry 0104 chemical sciences Chemistry Enzyme chemistry Moritella profunda biology.protein Biophysics Mesophile

description

Protein isotope labeling is a powerful technique to probe functionally important motions in enzyme catalysis and can be applied to investigate the conformational dynamics of proteins.

year	journal	country	edition	language
2015-11-05	Chemical Science

https://doi.org/10.1039/c5sc04209g

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