6533b7cffe1ef96bd125995c
RESEARCH PRODUCT
Nanofibrillar scaffold resists to bile and urine action: experiences in pigs
Calogero FioricaBianca CudiaS. FazzottaPietro GenovaA.i. LomonteGiuseppe DamianoVincenzo Davide PalumboMariano LicciardiSilvio BuscemiFabio Salvatore PalumboGirolamo Geracisubject
bile duct injury bladder injury gallbladder repair 3D matrix porcine models PHEA-PLA+PCLSettore MED/18 - Chirurgia GeneraleScaffoldAction (philosophy)Settore CHIM/09 - Farmaceutico Tecnologico ApplicativoChemistrySurgeryUrinePharmacologydescription
Biomaterial-based-scaffolds’ functions are to replace anatomical and functional features loss of an injured tissue. They can replace native tissue after their reabsorption. Material and methods. In our experimental procedures we utilized the PHEA-PLA+PCL scaffold in 2 female pigs to assess its resistance to bile and urine. Results. Both pigs survived to surgical procedures. After a month fibres appeared unchanged in term of form and dimension at electronic microscopy. Cells and ECM factors were founded inside the scaffold in a microscopical evaluation. Conclusion. Planar and tubular scaffolds were colonized by cells and extracellular matrix elements. The study conducted on pig suggested that this type of material can resist to the action of bile and urine. This material could be proposed as a tissue substitute.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2020-01-01 | Clinical and Experimental Surgery. Petrovsky journal |