6533b7cffe1ef96bd1259a03
RESEARCH PRODUCT
Equal distribution of T-lymphocyte subpopulations in thymus and spleen cells of NZB and BALB/c mice
D. V. SteldernU. BotzenhardtJ. Müller-quernheimsubject
Agingmedicine.medical_specialtymedicine.drug_classT-LymphocytesImmunologychemical and pharmacologic phenomenaSpleenThymus GlandMonoclonal antibodyBALB/cLeukocyte CountMiceRheumatologyInternal medicinemedicineAnimalsImmunology and AllergyDistribution (pharmacology)Autoimmune diseaseMice Inbred BALB CMice Inbred NZBbiologySignificant differenceT lymphocyteFlow Cytometrybiology.organism_classificationmedicine.diseaseRheumatologymedicine.anatomical_structureImmunologySpleendescription
NZB mice develop an autoimmune disease of unknown etiology. Since the detection of immunoregulatory T-cells it has been speculated that disbalances of these cells may be important in the course of the NZB disease. By utilization of monoclonal antibody defining immunoregulatory Lyt subsets and a FACS IV system we investigated whether differences in the number and/or marker densities of given subsets exist between NZB and the normal reference strain BALB/c. Newborn animals and animals up to 60 weeks of age were tested. No significant difference in the percentages nor in the marker densities of theta+, Lyt 1+, and Lyt 2+ cells was observed at any age or sex, neither in spleen nor in thymus. It is concluded the autoimmune disease of NZB is not influenced by the parameters investigated.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1984-03-01 | Rheumatology International |