6533b7cffe1ef96bd1259a30
RESEARCH PRODUCT
A hypotensive procyanidin-glycoside from Rhamnus lycioides ssp. lycioides.
Maria-jesus SanzMiguel PayáMaría Carmen Terenciosubject
MaleMagnetic Resonance SpectroscopyStereochemistryBlood PressurePharmacognosyCatechinchemistry.chemical_compoundDrug DiscoveryAnimalsBiflavonoidsProanthocyanidinsGlycosidesRhamnusChromatography High Pressure LiquidPharmacologychemistry.chemical_classificationCarbon IsotopesChromatographyPlants MedicinalbiologyDose-Response Relationship DrugChemistryPlant ExtractsRhamnus lycioidesGlycosideCatechinRats Inbred StrainsPlantsbiology.organism_classificationRatsPlants ToxicRhamnusProanthocyanidinRhamnaceaeAcid hydrolysisHypotensiondescription
A lyophilized hot water extract of the aerial parts of Rhamnus lycioides L. (Rhamnaceae) produced a lowering of systemic arterial blood pressure in normotensive anaesthetized Wistar rats. An activity-guided fractionation of the methanolic extract led to the isolation of a tetrameric procyanidin-glycoside which produced a clear dose-dependent hypotensive response (1.5-6 mg/kg i.v.). This principle was characterized using acid hydrolysis, thiolytic degradation and spectroscopic methods. It consisted of four flavanol units with a 2,3-cis configuration and with a O-beta-d-glucosylpyranoside function on the epicatechin terminal unit. The interflavan linkage was (4-8).
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1990-09-01 | Journal of ethnopharmacology |