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RESEARCH PRODUCT
Halloysite nanotubes as a carrier of cornelian cherry (Cornus mas L.) bioactives
Filippo ParisiBoris PopovićDragana ČEtojević-siminGiuseppe LazzaraBojana Blagojevićsubject
0106 biological sciencesIridoidChemistrymedicine.drug_classfood and beveragesHalloysite04 agricultural and veterinary sciencesengineering.materialCornelian cherryBioactivity040401 food science01 natural sciencesHalloysiteAnthocyanins0404 agricultural biotechnologyProlonged release010608 biotechnologyengineeringmedicineIridoidsAntiproliferative effectMCF7 CellsFood ScienceNuclear chemistrydescription
Abstract Cornelian cherry fruit extract rich in anthocyanins and iridoids was encapsulated in the halloysite nanotubes in order to obtain a stable nanoscale system for better delivery and prolonged release of bioactive constituents. The cyclic vacuum technique was used for halloysite nanotubes-cornelian cherry composite preparation and the loading of 8.5 wt% was achieved. Pure cornelian cherry extract exhibited antiproliferative effect on HT-29, MCF7, and MRC-5 cells, pristine halloysite nanotubes affected the growth of MCF7 cells, while halloysite nanotubes-cornelian cherry composites demonstrated proliferative activity in all tested cells. The sustained release of anthocyanins was achieved by this encapsulation strategy. Additional implementation of halloysite nanotubes-cornelian cherry into yogurt prolonged the release of iridoid molecules. Obtained results indicate that halloysite nanoclay is a suitable nanocarrier for cornelian cherry constituents that can be utilized in food and pharmaceutical industries.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2020-12-01 | LWT |