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RESEARCH PRODUCT
New susceptibility locus for coronary artery disease on chromosome 3q22.3
Nour Eddine El MokhtariDiana RubinDavid AltshulerLaurence TiretPhilipp S. WildJens BaumertStefan BlankenbergZouhair AherrahrouFrançois CambienJohn R. ThompsonAlistair S. HallJürgen SchrezenmeirThomas MeitingerHarald KlüterHeribert SchunkertWillem H. OuwehandAndreas ZieglerClaire PerretDiego ArdissinoArnika Kathleen WagnerPiera Angelica MerliniArne SchillertLuisa BernardinelliLuisa BernardinelliArne SchäferChrista MeisingerRoberto ElosuaStephen G. BallStephen M. SchwartzChristopher J. O'donnellPatrick Linsel-nitschkeMarcus FischerLeena PeltonenPetra BruseDavid S. SiscovickVeikko SalomaaSekar KathiresanStefan SchreiberNilesh J. SamaniWinfried MärzWinfried MärzWinfried MärzDavid-alexandre TrégouëtInke R. KönigJeanette ErdmannTanja ZellerPanos DeloukasPeter BugertBenjamin F. VoightBen J WrightChristian HengstenbergPeter S. BraundAnika GroßhennigOlle MelanderKlaus StarkH-erich WichmannAnthony J. BalmforthDaniel F SchwarzFlora PeyvandiAnnette PetersWilfried Rennersubject
medicine.medical_specialtyQuantitative Trait LociLocus (genetics)Single-nucleotide polymorphismGenome-wide association studyCoronary Artery DiseaseQuantitative trait locusBiologyBioinformaticsPolymorphism Single NucleotideArticleCoronary artery diseaseGermanyInternal medicineGeneticsmedicineHumansGenetic Predisposition to DiseaseHepatocyte Nuclear Factor 1-alphaMyocardial infarctionCase-control studyChromosomemedicine.diseaseCase-Control Studiesras ProteinsCardiologyChromosomes Human Pair 3Genome-Wide Association Studydescription
We present a three-stage analysis of genome-wide SNP data in 1,222 German individuals with myocardial infarction and 1,298 controls, in silico replication in three additional genome-wide datasets of coronary artery disease (CAD) and subsequent replication in approximately 25,000 subjects. We identified one new CAD risk locus on 3q22.3 in MRAS (P = 7.44 x 10(-13); OR = 1.15, 95% CI = 1.11-1.19), and suggestive association with a locus on 12q24.31 near HNF1A-C12orf43 (P = 4.81 x 10(-7); OR = 1.08, 95% CI = 1.05-1.11).
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2009-02-08 |