6533b7cffe1ef96bd1259afb
RESEARCH PRODUCT
Two new sesquiterpene derivatives from the Tunisian endemic Ferula tunetana Pom.
Jean-françois MirjoletHichem Ben JannetFethia Harzallah-skhiriMarie Aleth Lacaille-duboisOlivier DuchampZine MighriAymen JabraneAymen Jabranesubject
Magnetic Resonance SpectroscopyStereochemistryBioengineeringSesquiterpeneBiochemistryPlant Rootschemistry.chemical_compoundStructure-Activity RelationshipPropiophenoneSpecies SpecificityCoumarinsCell Line TumorHumansCytotoxicityMolecular BiologyCell ProliferationStigmasterolMs analysisGeneral ChemistryGeneral MedicineCoumarinAntineoplastic Agents PhytogenicUmbellipreninFerulachemistryFerula tunetanaMolecular MedicineDrug Screening Assays AntitumorSesquiterpenesdescription
A new sesquiterpene ester, tunetanin A (1), a new sesquiterpene coumarin, tunetacoumarin A (2), together with eight known compounds, i.e., coladin (3), coladonin (4), isosmarcandin (5), 13-hydroxyfeselol (6), umbelliprenin (7) propiophenone (8), beta-sitosterol (9), and stigmasterol (10), were isolated from the roots of Ferula tunetana. Their structures were elucidated on the basis of extensive spectroscopic methods, including 1D- and 2D-NMR experiments and MS analysis, as well as by comparison with published data. The cytotoxicity of compounds 1-7 towards two human colon cancer cell lines, HT-29 and HCT 116, was evaluated. Compounds 3, 4, and 6 showed weak cytotoxic activities.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2010-02-13 | Chemistrybiodiversity |