6533b7cffe1ef96bd1259b01

RESEARCH PRODUCT

Analysis of HLA-DQA, HLA-DQB frequencies in a group of Sardinian centenarians

Giuseppina Colonna-romanoLuigi FerrucciLuca DeianaLetizia ScolaMario G. PesCiriaco CarruDomenico LioCalogero CarusoGiovannella BaggioCrivello AGiuseppina CandoreGiusi Irma ForteClaudio Franceschi

subject

GeneticsAged 80 and overAgingeducation.field_of_studymedia_common.quotation_subjectPopulationConfoundingLongevityLongevityAnalysis of HLA-DQA HLA-DQBHuman leukocyte antigenBiologyHLA-DQ alpha-ChainsHLA-DQ AntigensTraitHLA-DQ beta-ChainsHumansGeriatrics and GerontologyAlleleAllele sharingeducationAllelesmedia_commonGenetic association

description

Human leukocyte antigen (HLA) alleles, regulating type and intensity of the immune response, might influence life expectancy. In previous case-control studies the authors have demonstrated that both HLA-DR and -DQ alleles are not associated with longevity in the Sardinian population. On the other hand, association studies are subjected (as part of the homogeneity of the population in terms of geographic origin) to a number of possible confounding factors. Therefore, the authors typed the HLA-DQA1 and HLA-DQB1 alleles in 24 sibs (age range 85 to 97) of 17 centenarians by PCR-SSP. Sib pair analysis showed non-significant differences between the observed and expected percentage of DQA* or DQB1* allele sharing. Therefore, these data strengthen the view that class II HLA genes have a marginal effect, if any, on the complex longevity trait.

yearjournalcountryeditionlanguage
2006-01-01
10.1089/rej.2006.9.157http://hdl.handle.net/10447/16103