Congenital pelvic skeletal anomalies: Clinical and radiographic evaluation of newborns with gastrointestinal malformation

6533b7cffe1ef96bd1259b07

RESEARCH PRODUCT

Congenital pelvic skeletal anomalies: Clinical and radiographic evaluation of newborns with gastrointestinal malformation

Marcello Cimador Giovanni Corsello Ingrid Anne Mandy Schierz Ettore Piro Giuseppa Pinello Mario Giuffrè

subject

Adult Male Pediatrics medicine.medical_specialty Skeletal anomalies Radiography Pelvic bones Musculoskeletal system Congenital abnormalities VACTERL association Radiography International classification of diseases Infant Newborn Diseases Pelvis medicine Humans business.industry Incidence Medical record Infant Newborn Obstetrics and Gynecology Odds ratio medicine.disease VACTERL association Hypoplasia Musculoskeletal Abnormalities Radiography Agenesis Pediatrics Perinatology and Child Health Female High incidence business Digestive System Abnormalities

description

Abstract Background Congenital pelvic skeletal anomalies (CPSA) may appear as isolated defects or in association with other anomalies like congenital malformations of the digestive system (CMDS). Minor CPSA in non-syndromic patients are often overlooked. We aimed to assess the frequency of CPSA in newborns with CMDS to review the diagnostic approaches. Study design A retrospective review of medical records of 201 newborns who underwent X-rays for different neonatal indications was conducted. In 122 patients CMDS were diagnosed and classified according to the ICD-10 classification; 79 non-CMDS patients acted as controls. Pelvic skeletal segments were examined by X-rays. Results Patients with CMDS, showed a higher risk of CPSA (Odds ratio 2.89; 95% CI 1.34 6.23) and other associated malformations in comparison to non-CMDS patients. Newborns with malformations of the large intestine have the highest risk of adjacent CPSA (48%), as it is a developmental defect originating from the same somite. In addition to skeletal agenesis/hypoplasia, we reported dysmorphic and bifid vertebras, trident ileum, and elongated neural arches. Conclusions The high incidence of CPSA in CMDS suggests performing a routine radiographic pelvic evaluation in cases of CMDS in order to identify complex phenotypes that could originate from the same developmental field.

year	journal	country	edition	language
2020-02-01

10.1016/j.earlhumdev.2019.104945 http://hdl.handle.net/10447/390417