6533b7d0fe1ef96bd125a1b5
RESEARCH PRODUCT
The synthesis of metallocene-labelled drugs for biological assays
I. LavastreJack BesanconClaude MoïseP. Brossiersubject
1h nmr spectroscopyChromatographymedicine.diagnostic_testChemistryGeneral ChemistryChemical synthesisInorganic Chemistrychemistry.chemical_compoundImmunoassay methodImmunoassaymedicineMass spectrumOrganic chemistryBioassayMetallocenedescription
Several drugs (amphetamine, desipramine, nortriptyline, phenobarbital) have been labelled with metallocenic fragments in order to develop a new immunoassay method. The metallocenic fragments are cymantrenic or benchrotrenic derivatives: the linkage between the organic and organometallic moieties has been achieved by reactions between amino and acidic functional groups. All the products (metallohaptens), purified by different chromatography techniques, have been fully characterized by IR and 1H NMR spectroscopy and their mass spectra.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1990-01-01 | Applied Organometallic Chemistry |