6533b7d0fe1ef96bd125a20a

RESEARCH PRODUCT

Isolation, structure elucidation, and biological evaluation of the unusual heterodimer chrysoxanthone from the ascomycete IBWF11-95A

Heinz KolshornJohannes C. LiermannHeidrun AnkeTill OpatzAnja Schüffler

subject

Diaryl etherStereochemistryMetaboliteOrganic ChemistryNuclear magnetic resonance spectroscopyIsolation (microbiology)Biochemistrychemistry.chemical_compoundchemistryMic valuesDrug DiscoveryAntibacterial activityMyceliumBiological evaluation

description

Chrysoxanthone, an unusual heterodimer of blennolide A and 2-hydroxychrysophanol linked through a diaryl ether bridge, was isolated from mycelia of the ascomycete IBWF11-95A grown in submerged culture. Its structure was elucidated by two-dimensional NMR spectroscopy. The metabolite shows antibacterial activity against different species with MIC values between 2.5 and 20 μg/mL while also inhibiting the growth of several fungi.

yearjournalcountryeditionlanguage
2009-08-01Tetrahedron Letters
https://doi.org/10.1016/j.tetlet.2009.06.008